Will Oregano Oil Kill a Tooth Nerve?

Written, Edited, and Reviewed by Dr David Chen.

Oregano oil can temporarily kill a tooth nerve because it’s an analgesic but it’s only effective in certain situations. That means despite its analgesic property, it may not provide you with the tooth pain relief that you’re seeking if you use it improperly.

We will explain what we mean by that and go over everything that you need to know about this essential oil.


However, you should keep in mind that the oil of oregano is still a home remedy which means it does not treat the tooth pain source. If you want to kill your tooth nerve permanently, you’ll need to see a dentist to treat the etiology of your toothache.

Does it work?

Oregano oil is an essential oil that is derived from the herb oregano (Origanum vulgare) and it can help alleviate a toothache.

It works because it is a legitimate analgesic and it’s anesthetic effects have been proven in research studies. Although it seems like the bulk of its beneficial effects stem from carvacrol, a phenolic monoterpenoid that is found in essential oils (oregano, thyme, pepperwort, wild bergamot, etc).

Carvacrol molecular structure
Carvacrol – Credit: Edgar181

In addition to the anesthetic potential, it also has a plethora of other helpful benefits as well.

It’s an analgesic

Studies have demonstrated that oregano oil or rather, carvacrol is an analgesic and can potentially be used for analgesia. We’ll provide three research studies as reference.

This study tested the numbing efficacy of carvacrol for orofacial pain.

  • Lips of rats were injected with carvacrol.
  • Scientists applied various irritants such as capsaicin (hot sauce) on the lips.
  • Results concluded that the essential oil was effective in blocking pain signals.

Analgesic effects of oregano oil was compared to morphine and fenoprofen.

  • Mice were injected with the above solutions.
  • Tail-flick method performed on mice to measure pain response.
  • Researchers found that oregano oil was effective in reducing pain and that it was linked to the carvacrol in the oil.
  • However, they also noticed that not all types of oregano oil produced the same result. The oil of oregano seems to be more effective from certain regions.

Researchers were trying to figure out how carvacrol inhibited pain but it appears as if it does so via different mechanisms than typical anesthetics.

  • Administering Naloxone (opioid antagonist) did not impede carvacrol’s activity. This implies that it does not work via the opioid pathways.
  • It also does not seem to be affected by nitric oxide pathways either.

In summary, this essential oil is a proven analgesic agent and will provide pain relief to all types of bodily ailments, which includes tooth pain.

Other benefits

The carvacrol has a wide range of benefits:

  • Antimicrobial
  • Antitumor
  • Antimutagenic
  • Antigenotoxic
  • Analgesic
  • Antispasmodic
  • Anti-inflammatory
  • Angiogenic
  • Antiparasitic
  • Antiplatelet
  • AChe inhibitory
  • Anti-elastase
  • Insecticidal
  • Antihepatotoxic and hepatoprotective activities

How to use it

There are three common ways to use oregano oil for toothaches.

  1. Add 1-2 drops of the essential oil into a cup of water.
  2. Rinse with it by swishing around for 1-2 minutes.
  3. Spit out and rinse out with water thoroughly.
  4. Repeat 2-3x per day.
  1. Place a drop of the essential oil directly over the affected tooth.
  2. Let it sit on your tooth for as long as possible.
  3. Spit out and rinse if you accumulate too much saliva.
  4. You don’t want to swallow excessive amounts of it.
  5. You may repeat this 2-3x a day.
  1. Squeeze a drop of oregano oil onto a cotton ball or q-tip.
  2. Dab it onto the affected tooth and surrounding gums.
  3. Leave it on the tooth for as long as possible.
  4. If you start pooling saliva, spit out.
  5. Rinse out thoroughly once you’ve finished.
  6. Repeat 2-3x per day as needed.

Where to buy

Oregano oil is readily available at most pharmacies and supermarkets in the vitamins and health supplement aisle. Alternatively you could always just purchase this online if you can’t find it in person.

How to make it

You can make your own oregano oil but it does require time to make it. It will definitely be faster if you purchase it and if you’re having pain, you may not be able to wait 2 weeks to make this.

  1. Bring water to a boil and turn off once it’s boiling.
  2. Place the carrier oil (olive oil) and crushed oregano leaves in a jar.
  3. Place the jar into the hot water and let it sit for 5-10 min.
  4. Remove the jar from the water and place in a sunny window for 1-2 weeks.
  5. Shake the jar every couple of days.
  6. Strain the oil from the leaves after 1-2 weeks.
  7. Place the oil back into the jar and store in a dark cool place.

Since there are no preservatives in this recipe, your DIY carvacrol oil may last only 3 months.

When it helps and doesn’t

Despite oregano oil’s tooth numbing potency it works most effectively if you’re able to apply it directly onto the tooth nerve. If you’re not able to place it into the pulp, the effectiveness dramatically decreases.

When oregano oil is effective for a toothache

The oregano oil is most effective at relieving a toothache when you have an exposed nerve. That means you’ve an open cavity or when a dentist drills a hole through the tooth to expose it.

It works because the essential oil is able to act directly on the inflamed and irritated tooth nerve. There is no physical barrier preventing this home remedy from exerting its analgesic effects.

When oregano oil doesn’t work

The oil of oregano is NOT effective if you’re trying to douse an intact tooth with it. The essential oil will never be able to penetrate through the layers of enamel and dentin to even reach the tooth nerve.

Tooth Anatomy - Mouthhealthy
Credit: Mouthhealthy – ADA

Nature has designed the pulp of the tooth to be protected and insulated from all external stimuli with layers of dentin and enamel. These layers protect it from injury and also your toothache home remedy. That is the unfortunate truth.

Your dentist is able to bypass these barriers by drilling a hole through your tooth, thus creating direct access to the pulp chamber. From there, they can place whatever nerve calming medication directly into it.

Is oregano oil safe?

This home remedy is relatively safe to use and unlikely to cause any adverse effects when used orally for a toothache since it is a food. However, it can be harmful when misused or abused in very high doses.

One research study tested use of oregano oil on rodents for 90 days straight. They determined that using up to 200 mg/kg of bodyweight of the oil per day was still safe. There were no observed side effects.

How much is 200 mg/kg of oregano oil?

  • We couldn’t find the exact amount for the essential oil but for the capsule version, there is 150 mg per capsule when taken by mouth.
  • The average adult male is 70kg when coverted from lbs which means you’d need to take well over 70 tablets for it even bypass the safety limits.
oregano supplement capsules

In summary, based on our findings, it is highly unlikely for you to ingest enough of this stuff to cause yourself harm.

Used in food

Food recipes with oregano:

  • Provoleta with Oregano and Tomatoes
  • Mussels with Speck, Lemon and Oregano
  • Grilled Shrimp with Oregano and Lemon
  • Pistachio-Oregano Pesto
  • Lemon-Oregano Roasted Chicken with Potatoes and Olives

At the end of the day, oregano IS a commonly used herb in many cuisines. We’ve all eaten enough of it in our lifetime so you should know that it is unlikely to cause harm. Nonetheless, the fact that it’s a food does not preclude it from adverse effects when you overdose on it.

Better alternative for toothache

A better toothache home remedy than oregano oil is taking pain medication. It will be more effective because it exerts its analgesic effects systemically rather than topically.

  • Pain medication are systemic. You swallow these painkillers and they get distributed via your blood stream. This helps it bypass the dentin and enamel which protect the nerve.
  • Essential oils are topical. Unfortunately the only way to apply these oils including oregano, are to use it topically. Rinsing or dabbing it on the tooth will have trouble reaching the pulp especially for an intact tooth.

Medication which works for a toothache:

  • Ibuprofen (Advil, motrin)
  • Acetaminophen (tylenol)
  • Aspirin

Best painkiller for toothache

In our opinion, the most effective toothache medication would be Advil dual action because it contains ibuprofen mixed with acetaminophen in its formulation. We consider it the most potent OTC painkiller on the market.

Advil dual action - ibuprofen with acetaminophen
Advil dual action – ibuprofen with acetaminophen

Studies have shown that when these two painkillers are taken together, they exert a greater analgesic effect than if you only took one of them. The reason is because they inhibit pain via slightly different mechanisms.

acetaminophen with ibuprofen pain relief chart
Credit: Paul A. Moore, DMD, PhD, MPH; Hersh Elliot V., DMD, MS, PhD

When to see a dentist

If you want to permanently kill your tooth nerve and prevent it from ever coming back again, you should see a dentist. There are only two known dental procedures that can get rid of your nagging dental pain forever.

  • Root canal. This endodontic procedure will physically remove the nerve from the tooth, thus separating it for good.
  • Tooth extraction. This surgical procedure will physically remove the entire tooth along with its nerve from your jaw.

Both of these methods require mechanical treatment of the tooth nerve. You’re not able to achieve this at home thus, all DIY home remedies will offer temporary relief at best if it works.

Tips on what to do in meantime

The best thing to do is book an appointment with your dentist. However, while you’re waiting to be seen here are some good practices to help minimize your discomfort.

  1. Brush after every meal. Yes, you want to reduce irritants in your mouth. Irritants can be residual foods, acids, and plaque.
  2. Rinse frequently with salt water. This helps to keep your mouth free of debris and plaque. It can also help neutralize acids and keep the mouth in a balanced pH.
  3. Take pain medication. Our recommendation is to take the advil dual action, which is the most potent OTC painkiller.
  4. Avoid activities which irritate the tooth. Whatever triggers it, don’t do those activities.

The Verdict

While oregano oil can temporarily kill a tooth nerve, it is unlikely to be effective when used as a home remedy. The only time it works well is if you have an exposed nerve where you can directly apply the essential oil with carvacrol to it.

However if your tooth is mostly intact and you’re having some type of tooth nerve pain, the oil from the oregano will not be able to penetrate through the layers of the teeth. This means there will be little to no soothing effect despite the proven analgesic properties.

We stand by that the best thing to do is see a dentist if you’re having a toothache. They can stop it quickly by directly treating the nerve instead of temporarily trying to cover up the pain.


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Our purpose at afterva, is to encourage you to seek in person care with a doctor. It's not meant to be a substitute for medical advice. Each situation is unique and that makes it impossible to diagnose and treat without a clinical exam.

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